CPC C07K 14/445 (2013.01) [A61K 35/68 (2013.01); A61K 38/16 (2013.01); A61K 38/45 (2013.01); A61K 39/015 (2013.01); A61K 49/00 (2013.01); A61K 49/0056 (2013.01); A61K 51/088 (2013.01); C07K 14/21 (2013.01); C07K 14/34 (2013.01); G01N 33/574 (2013.01); G01N 33/57484 (2013.01); A61K 38/00 (2013.01); C07K 2319/33 (2013.01); C12Y 204/02036 (2013.01); G01N 2333/47 (2013.01); G01N 2333/70585 (2013.01)] | 13 Claims |
1. A conjugate or a fusion protein comprising an isolated VAR2CSA polypeptide and a diagnostic effector moiety, wherein said VAR2CSA polypeptide comprises
a wild-type ID1-DBL2Xb sequence having at least 70% sequence identity to the full-length sequence set forth in SEQ ID NO: 1 and has the functional activity of binding to chondroitin sulfate A (CSA), or
a wild-type ID1-DBL2Xb sequence in the form of a functional fragment of SEQ ID NO: 1 that is between 570 and 640 amino acids in length, wherein the functional fragment has the functional activity of binding to CSA,
wherein said diagnostic effector moiety is a magnetic bead capable of being detected upon binding of said conjugate to CSA expressed on cancer cells.
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