CPC C07D 413/04 (2013.01) [A61K 45/06 (2013.01); A61P 35/00 (2018.01)] | 10 Claims |
1. A benzimidazole derivative of formula (I), or an isomer, or a pharmaceutically-acceptable salt thereof:
wherein x is 0, 1, or 2;
when m is 0, n is 2; and when m is 1, n is 1;
y is 0, 1, 2, 3 or 4; R1 is each independently halogen, phenolic hydroxyl or a derivative thereof, carboxyl or a derivative thereof, an amino group or a derivative thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, sulfone or a sulphoxide derivative, a C1-C15 alkyl group or a derivative thereof, a C1-C15 alkenyl or a derivative thereof, a C1-C15 alkynyl or a derivative thereof, a C5-C8 aryl or a derivative thereof, naphthyl or a naphthol derivative, or a five-to-eight-membered heterocyclic or fused heterocyclic ring containing 1-4 heteroatoms;
R2 is an amino group or a derivative thereof; and
z is 0, 1, 2, 3 or 4; R3 is each independently halogen, phenolic hydroxyl or a derivative thereof, carboxyl or a derivative thereof, an amino group or a derivative thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, sulfone or a sulfoxide derivative, a C1-C15 alkyl group or a derivative thereof, a C1-C15 alkenyl or a derivative thereof, a C1-C15 alkynyl or a derivative thereof, a C5-C8 aryl or a derivative thereof, naphthyl or a naphthol derivative, or a five-to-eight-membered heterocyclic or fused heterocyclic ring containing 1-4 heteroatoms.
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