US 11,787,790 B2
Benzimidazole derivative having fluorine-containing substituent, preparation and application thereof
Zhengwu Shen, Shanghai (CN)
Assigned to YUNBAIYAO ZHENGWU SCIENCE AND TECHNOLOGY (SHANGHAI) CO., LTD., Shanghai (CN)
Filed by YUNBAIYAO ZHENGWU SCIENCE AND TECHNOLOGY (SHANGHAI) CO., LTD., Shanghai (CN)
Filed on Sep. 19, 2022, as Appl. No. 17/947,260.
Application 17/947,260 is a continuation of application No. PCT/CN2021/077769, filed on Feb. 25, 2021.
Claims priority of application No. 202010338743.5 (CN), filed on Apr. 26, 2020.
Prior Publication US 2023/0040251 A1, Feb. 9, 2023
Int. Cl. C07D 413/04 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01)
CPC C07D 413/04 (2013.01) [A61K 45/06 (2013.01); A61P 35/00 (2018.01)] 10 Claims
 
1. A benzimidazole derivative of formula (I), or an isomer, or a pharmaceutically-acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein x is 0, 1, or 2;
when m is 0, n is 2; and when m is 1, n is 1;
y is 0, 1, 2, 3 or 4; R1 is each independently halogen, phenolic hydroxyl or a derivative thereof, carboxyl or a derivative thereof, an amino group or a derivative thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, sulfone or a sulphoxide derivative, a C1-C15 alkyl group or a derivative thereof, a C1-C15 alkenyl or a derivative thereof, a C1-C15 alkynyl or a derivative thereof, a C5-C8 aryl or a derivative thereof, naphthyl or a naphthol derivative, or a five-to-eight-membered heterocyclic or fused heterocyclic ring containing 1-4 heteroatoms;
R2 is an amino group or a derivative thereof; and
z is 0, 1, 2, 3 or 4; R3 is each independently halogen, phenolic hydroxyl or a derivative thereof, carboxyl or a derivative thereof, an amino group or a derivative thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, sulfone or a sulfoxide derivative, a C1-C15 alkyl group or a derivative thereof, a C1-C15 alkenyl or a derivative thereof, a C1-C15 alkynyl or a derivative thereof, a C5-C8 aryl or a derivative thereof, naphthyl or a naphthol derivative, or a five-to-eight-membered heterocyclic or fused heterocyclic ring containing 1-4 heteroatoms.