CPC C07D 401/14 (2013.01) [C07D 231/56 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 487/04 (2013.01)] | 28 Claims |
1. A compound having the structure of Formula IVa:
or a pharmaceutically acceptable salt thereof, wherein
R1 is heterocycloalkyl having 5 to 6 ring members and 1 to 2 heteroatoms each N, phenyl or a heteroaryl having 5 to 6 ring members and 1 to 2 heteroatoms each N or S, each substituted with 1 to 3 R1a groups;
each R1a is independently hydrogen, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 alkoxy, C1-3 hydroxyalkyl, halogen, C1-3 haloalkyl, oxo, —CN, C3-6 cycloalkyl, or heterocycloalkyl having 3 to 5 ring members and 1 to 2 heteroatoms each N or O;
A1, A2, A3 and A4 are each independently ═CR2— or ═N—;
each R2 is independently hydrogen, C1-6 alkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, hydroxy or —CN;
each R3a is independently hydrogen, OH, or oxo;
R3b is C1-6 alkyl, C2-6 alkynyl, C2-6 alkoxyalkyl, C2-6 alkynyl-C3-6 cycloalkyl, C1-6 alkyl-C6-12 aryl, C2-6 alkenyl-C6-12 aryl, C2-6 alkynyl-C6-12 aryl, C1-6 alkyl-O-C6-12 aryl, C1-6 alkoxyalkyl-C6-12 aryl, —C(O)—C6-12 aryl, or C1-6 alkyl-heteroaryl, wherein each heteroaryl has 5 to 10 ring members and 1 to 3 heteroatoms each independently N, O or S, and wherein each aryl and heteroaryl are substituted with 1 to 3 R3b3 groups;
each R3b3 is hydrogen, C1-6 alkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, C1-6 hydroxyalkyl, halogen, C1-6 haloalkyl, or C1-6 haloalkoxy;
R4 is C1-6 alkyl, C1-6 haloalkyl, —CN, C3-8 cycloalkyl, 3 to 8 membered heterocycloalkyl having 1 to 3 heteroatoms each independently N, O or S, C6-12 aryl, or 5 to 10 membered heteroaryl having 1 to 5 heteroatoms each independently N, O or S, wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl are each independently substituted with 1 to 5 R4a groups;
each R4a is hydrogen, C1-6 alkyl, C1-6 deuteroalkyl, C1-6 alkoxy, C2-6 alkoxyalkyl, C1-6 hydroxyalkyl, halogen, C1-6 haloalkyl, —CN, —OH, oxo, —S(O)2R4b, —S(O)2N(R4b)(R4c), C3-6 cycloalkyl, C6-12 aryl, C6-12 aryl, wherein each aryl is optionally substituted with C1-6 alkoxy;
each R4b and R4c is hydrogen or C1-6 alkyl;
L1 is absent; and
L2 is absent, —CH2—, —C(O)—, —C(O)CH2—, —C(O)CH2CH2—, —C(O)CH2O—, —C(O)(CH2)3O—, or —S(O)2.
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