US 11,787,766 B2
Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof
Lei Jiang, Shanghai (CN); Jianwen Deng, Shanghai (CN); Xiaoli Lu, Shanghai (CN); Ke Shang, Shanghai (CN); Jianyong Shou, Shanghai (CN); Bing Wang, Shanghai (CN); Danyi Wu, Shanghai (CN); Xueli Xu, Shanghai (CN); Yuan Xu, Shanghai (CN); Yi Zhang, Shanghai (CN); and Mingwei Zheng, Shanghai (CN)
Assigned to SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD., Shanghai (CN)
Appl. No. 16/639,949
Filed by SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD., Shanghai (CN)
PCT Filed Aug. 17, 2018, PCT No. PCT/CN2018/101191
§ 371(c)(1), (2) Date Jun. 29, 2020,
PCT Pub. No. WO2019/034172, PCT Pub. Date Feb. 21, 2019.
Claims priority of application No. 201710712191.8 (CN), filed on Aug. 18, 2017.
Prior Publication US 2020/0392083 A1, Dec. 17, 2020
Int. Cl. C07D 213/69 (2006.01); C07D 213/73 (2006.01); C07D 213/84 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 519/00 (2006.01); A61K 31/137 (2006.01); A61K 31/165 (2006.01); A61K 31/4155 (2006.01); A61K 31/437 (2006.01); A61K 31/44 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 39/12 (2006.01); A61K 39/245 (2006.01); A61K 39/29 (2006.01); A61K 45/06 (2006.01); C07C 211/03 (2006.01); C07C 223/02 (2006.01); C07D 231/40 (2006.01)
CPC C07D 213/69 (2013.01) [A61K 31/137 (2013.01); A61K 31/165 (2013.01); A61K 31/4155 (2013.01); A61K 31/437 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 39/12 (2013.01); A61K 39/245 (2013.01); A61K 39/29 (2013.01); A61K 45/06 (2013.01); C07C 211/03 (2013.01); C07C 223/02 (2013.01); C07D 213/73 (2013.01); C07D 213/84 (2013.01); C07D 231/40 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 519/00 (2013.01)] 3 Claims
 
1. A compound selected from the following group, or a stereoisomer, a racemate, or a pharmaceutically acceptable salt thereof,
 
 
 
No. Structure of compound
 
 
 
 
6
 

OG Complex Work Unit Chemistry
 
 
 
9
 

OG Complex Work Unit Chemistry
 
 
 
17
 

OG Complex Work Unit Chemistry
 
 
 
20
 

OG Complex Work Unit Chemistry
 
 
 
22
 

OG Complex Work Unit Chemistry
 
 
 
 
 
24
 

OG Complex Work Unit Chemistry
 
 
 
26
 

OG Complex Work Unit Chemistry
 
 
 
27
 

OG Complex Work Unit Chemistry
 
 
 
28
 

OG Complex Work Unit Chemistry
 
 
 
30
 

OG Complex Work Unit Chemistry
 
 
 
33
 

OG Complex Work Unit Chemistry
 
 
 
35
 

OG Complex Work Unit Chemistry
 
 
 
37
 

OG Complex Work Unit Chemistry
 
 
 
39
 

OG Complex Work Unit Chemistry
 
 
 
41
 

OG Complex Work Unit Chemistry
 
 
 
42
 

OG Complex Work Unit Chemistry
 
 
 
43
 

OG Complex Work Unit Chemistry
 
 
 
46
 

OG Complex Work Unit Chemistry
 
 
 
47
 

OG Complex Work Unit Chemistry
 
 
 
48
 

OG Complex Work Unit Chemistry
 
 
 
49
 

OG Complex Work Unit Chemistry
 
 
 
50
 

OG Complex Work Unit Chemistry
 
 
 
51
 

OG Complex Work Unit Chemistry
 
 
 
52
 

OG Complex Work Unit Chemistry
 
 
 
53
 

OG Complex Work Unit Chemistry
 
 
 
54
 

OG Complex Work Unit Chemistry
 
 
 
55
 

OG Complex Work Unit Chemistry
 
 
 
56
 

OG Complex Work Unit Chemistry
 
 
 
57
 

OG Complex Work Unit Chemistry
 
 
 
58
 

OG Complex Work Unit Chemistry
 
 
 
59
 

OG Complex Work Unit Chemistry
 
 
 
60
 

OG Complex Work Unit Chemistry
 
 
 
61
 

OG Complex Work Unit Chemistry
 
 
 
62
 

OG Complex Work Unit Chemistry
 
 
 
63
 

OG Complex Work Unit Chemistry
 
 
 
64
 

OG Complex Work Unit Chemistry
 
 
 
65
 

OG Complex Work Unit Chemistry
 
 
 
66
 

OG Complex Work Unit Chemistry
 
 
 
67
 

OG Complex Work Unit Chemistry
 
 
 
68
 

OG Complex Work Unit Chemistry
 
 
 
69
 

OG Complex Work Unit Chemistry
 
 
 
70
 

OG Complex Work Unit Chemistry
 
 
 
71
 

OG Complex Work Unit Chemistry
 
 
 
72
 

OG Complex Work Unit Chemistry
 
 
 
73
 

OG Complex Work Unit Chemistry
 
 
 
74
 

OG Complex Work Unit Chemistry
 
 
 
75
 

OG Complex Work Unit Chemistry
 
 
 
76
 

OG Complex Work Unit Chemistry
 
 
 
77
 

OG Complex Work Unit Chemistry
 
 
 
78
 

OG Complex Work Unit Chemistry
 
 
 
79
 

OG Complex Work Unit Chemistry
 
 
 
80
 

OG Complex Work Unit Chemistry
 
 
 
81
 

OG Complex Work Unit Chemistry
 
 
 
82
 

OG Complex Work Unit Chemistry