| CPC A61L 27/46 (2013.01) [A61L 27/48 (2013.01); A61L 27/58 (2013.01)] | 5 Claims |
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1. A method for preparing a biomedical composite material, comprising:
preparing a substrate particle comprising calcium phosphate;
mixing the substrate particle with a first reactive monomer to obtain a mixed solution;
adding a catalyst to the mixed solution, heating to 80° C. to 180° C. in an inert gas, and reacting for 2 hours to 48 hours, such that an intermediate layer composed of the first reactive monomer is coated on the substrate particle; and
adding a second reactive monomer, maintaining heating, and continuing for 2 hours to 48 hours to form a polymer matrix on the intermediate layer;
wherein:
the first reactive monomer is at least one item selected from the group consisting of lactide, caprolactone, p-dioxanone, and glycolide;
the second reactive monomer is at least one item selected from the group consisting of lactide, caprolactone, p-dioxanone, and glycolide;
the biomedical composite material comprises 1 wt % to 10 wt % of the intermediate layer;
the substrate particle is covalently bonded to the intermediate layer; and
the intermediate layer and the polymer matrix do not form a stereocomplex.
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