US 11,786,634 B2
Demineralized bone matrix having improved handling characteristics
Kerem N. Kalpakci, Memphis, TN (US); and Daniel A. Shimko, Germantown, TN (US)
Assigned to Warsaw Orthopedic, Inc., Warsaw, IN (US)
Filed by WARSAW ORTHOPEDIC, INC., Warsaw, IN (US)
Filed on Aug. 30, 2021, as Appl. No. 17/461,867.
Application 17/461,867 is a division of application No. 15/902,038, filed on Feb. 22, 2018, granted, now 11,103,618.
Prior Publication US 2021/0386910 A1, Dec. 16, 2021
Int. Cl. A61L 27/36 (2006.01); A61L 27/12 (2006.01); A61L 27/14 (2006.01); A61L 27/20 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61L 27/48 (2006.01)
CPC A61L 27/3608 (2013.01) [A61L 27/12 (2013.01); A61L 27/14 (2013.01); A61L 27/20 (2013.01); A61L 27/48 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 2400/06 (2013.01); A61L 2400/12 (2013.01); A61L 2430/02 (2013.01)] 15 Claims
 
1. A method of making an injectable or moldable implant, the method comprising mixing lyophilized demineralized bone matrix (DBM) being in fiber and particle forms in an amount of about 28% based on a total weight of the implant, or DBM in fiber, particle and chip forms in an amount of about 30% based on the total weight of the implant with an aqueous liquid comprising an alginate so as to uniformly distribute the DBM within the alginate to form the injectable or moldable implant, the alginate is in an amount of from about 1 wt. % to about 10 wt. % of the total weight of the injectable implant, and the injectable implant does not contain any collagen in addition to the demineralized bone matrix (DBM), and the fiber has an aspect ratio of about 50:1 to about 1000:1, wherein the injectable implant is an aseptically processed injectable implant.