	US 11,786,594 B2
	Spiky metal organic framework, method for fabricating thereof, and kit for treating cancer
Hsing-Wen Sung, Hsinchu (TW); Po-Ming Chen, New Taipei (TW); Wen-Yu Pan, Taipei (TW); Yang-Bao Miao, Hsinchu (TW); and Po-Kai Luo, Chiayi County (TW)
Assigned to NATIONAL TSING HUA UNIVERSITY, Hsinchu (TW)
Filed by NATIONAL TSING HUA UNIVERSITY, Hsinchu (TW)
Filed on Mar. 18, 2021, as Appl. No. 17/205,732.
Claims priority of application No. 109120643 (TW), filed on Jun. 18, 2020.
Prior Publication US 2021/0393781 A1, Dec. 23, 2021
Int. Cl. A61K 41/00 (2020.01); C07F 5/06 (2006.01); C07F 15/00 (2006.01); A61K 39/395 (2006.01); A61N 5/06 (2006.01); A61K 9/14 (2006.01)

CPC A61K 41/0057 (2013.01) [A61K 9/14 (2013.01); A61K 39/3955 (2013.01); A61N 5/062 (2013.01); C07F 5/069 (2013.01); C07F 15/0053 (2013.01); A61N 2005/066 (2013.01); A61N 2005/0659 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/0662 (2013.01)]

8 Claims

1. A spiky metal organic framework formed by a coordination reaction between at least one metal ion and an organic ligand, the spiky metal organic framework comprising:

a body being a spherical shape, wherein a particle size of the body is 1 μm to 3 μm; and

a plurality of spike-like structures, wherein the spike-like structures are distributed on a surface of the body, a diameter of each spike-like structure is 15 nm to 35 nm, and a length of each spike-like structure is 250 nm to 400 nm;

wherein the at least one metal ion is aluminum ion, ruthenium ion, cobalt ion or iron ion, and the organic ligand is 2-aminoterephthalic acid or terephthalic acid.