	US 11,786,586 B2
	Carbohydrate structures and uses thereof
Horacio Uri Saragovi, Montreal (CA)
Assigned to AOA Dx, Boulder, CO (US)
Appl. No. 16/471,738
Filed by AOA Dx, Boulder, CO (US)
PCT Filed Dec. 22, 2017, PCT No. PCT/CA2017/051603 § 371(c)(1), (2) Date Jun. 20, 2019, PCT Pub. No. WO2018/112669, PCT Pub. Date Jun. 28, 2018.
Claims priority of provisional application 62/438,924, filed on Dec. 23, 2016.
Prior Publication US 2019/0343941 A1, Nov. 14, 2019
Int. Cl. A61K 39/00 (2006.01); A61K 39/385 (2006.01); C07K 16/30 (2006.01); A61P 35/04 (2006.01); C07H 15/203 (2006.01); A61P 37/04 (2006.01); A61P 35/00 (2006.01); C40B 40/02 (2006.01); A61P 31/20 (2006.01); A61P 31/14 (2006.01); C40B 30/04 (2006.01); A61P 31/04 (2006.01); A61P 31/18 (2006.01)

CPC A61K 39/001171 (2018.08) [A61K 39/385 (2013.01); A61P 31/04 (2018.01); A61P 31/14 (2018.01); A61P 31/18 (2018.01); A61P 31/20 (2018.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); A61P 37/04 (2018.01); C07H 15/203 (2013.01); C07K 16/3084 (2013.01); C40B 30/04 (2013.01); C40B 40/02 (2013.01); A61K 2039/6081 (2013.01); A61K 2039/6093 (2013.01); A61K 2039/627 (2013.01)]

18 Claims

1. A cancer vaccine comprising a carbohydrate structure having the formula

[(A)-(P)y-(L)z]x-M

wherein

A is a carbohydrate antigen, or any portion thereof;

P is a ring;

L is a linker;

z is 0 or 1;

x is an integer from 1 to 32;

M is a core;

and

wherein y is 1, and P is not C6-C10 aryl;

wherein the carbohydrate antigen is selected from the group consisting of GD2, GD3, GD1b, GT1b, fucosyl-GM1, GloboH, polysialic acid (PSA), GM2, GM3, sialyl-LewisX, sialyl-LewisY, sialyl-LewisA, sialyl-LewisB, and LewisY,

wherein M is selected from the group consisting of a branched polymer and a micelle, wherein M is not keyhole limpet hemocyanin (KLH), a nucleic acid, or a polypeptide.