US 11,786,569 B2
Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
Greg M. Delgoffe, Pittsburgh, PA (US); Dayana Rivadeneira, Pittsburgh, PA (US); Padmavathi Sampath, Pittsburgh, PA (US); and Stephen H. Thorne, Pittsburgh, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Appl. No. 16/959,025
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
PCT Filed Jan. 28, 2019, PCT No. PCT/US2019/015434
§ 371(c)(1), (2) Date Jun. 29, 2020,
PCT Pub. No. WO2019/148109, PCT Pub. Date Aug. 1, 2019.
Claims priority of provisional application 62/622,547, filed on Jan. 26, 2018.
Prior Publication US 2020/0330534 A1, Oct. 22, 2020
Int. Cl. A61K 38/00 (2006.01); A61K 35/763 (2015.01); A61P 35/00 (2006.01); A61K 35/768 (2015.01); C07K 14/495 (2006.01); C07K 14/54 (2006.01); C07K 14/545 (2006.01); C07K 14/55 (2006.01); C07K 14/56 (2006.01); C07K 14/57 (2006.01); C07K 14/575 (2006.01); C12N 7/00 (2006.01); A61K 45/06 (2006.01)
CPC A61K 35/763 (2013.01) [A61K 35/768 (2013.01); A61P 35/00 (2018.01); C07K 14/495 (2013.01); C07K 14/545 (2013.01); C07K 14/5406 (2013.01); C07K 14/5418 (2013.01); C07K 14/5425 (2013.01); C07K 14/5428 (2013.01); C07K 14/5437 (2013.01); C07K 14/5443 (2013.01); C07K 14/55 (2013.01); C07K 14/56 (2013.01); C07K 14/57 (2013.01); C07K 14/5759 (2013.01); C12N 7/00 (2013.01); A61K 45/06 (2013.01)] 20 Claims
 
1. A recombinant oncolytic virus, comprising:
a nucleic acid molecule encoding one or more metabolic modulating proteins, wherein the one or more metabolic modulating proteins is leptin, adiponectin, apelin, or chemerin.