	US 11,786,564 B2
	Probiotic immunomodulatory compositions
Aki Sinkkonen, Lahti (FI); Mira Grönroos, Lahti (FI); Heikki Hyöty, Tampere (FI); Olli-Heikki Laitinen, Tampere (FI); Noora Nurminen, Tampere (FI); and Sami Oikarinen, Tampere (FI)
Assigned to Uute Scientific Oy, Lohja (FI)
Filed by Uute Scientific Oy, Lohja (FI)
Filed on Apr. 6, 2022, as Appl. No. 17/714,205.
Application 17/714,205 is a continuation of application No. 16/466,405, granted, now 11,318,173, previously published as PCT/FI2017/050868, filed on Dec. 7, 2017.
Claims priority of application No. 20165932 (FI), filed on Dec. 7, 2016.
Prior Publication US 2022/0354906 A1, Nov. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/02 (2015.01); A61K 35/742 (2015.01); A61K 8/96 (2006.01); A61K 8/99 (2017.01); A61K 9/00 (2006.01); A61K 35/10 (2015.01); A61K 35/747 (2015.01); A61K 35/00 (2006.01); A61K 35/12 (2015.01)

CPC A61K 35/742 (2013.01) [A61K 8/965 (2013.01); A61K 8/99 (2013.01); A61K 9/0014 (2013.01); A61K 35/10 (2013.01); A61K 35/747 (2013.01); A61K 2035/115 (2013.01); A61K 2035/122 (2013.01)]

10 Claims

1. A food ingredient comprising a microbial community of non-culturable bacteria, wherein:

i. the microbial diversity is at least 3 at Shannon diversity index;

ii. the microbial richness is at least 130 operational taxonomic units;

iii. the microbial abundance is at least 1,000,000 bacterial 16S copies g⁻¹ww; and

the abundance of pathogens is below 500 16S gene sequences per 0.25 g sample in bacterial genera Acinetobacter, Actinomyces, Aerococcus, Aeromonas, Arcobacter, Bacillus, Bacteroides, Bifidobacterium, Brevibacillus, Brevundimonas, Chryseobacterium, Corynebacterium, Fibrobacter, Finegoldia, Gemella, Lactobacillus, Legionella, Leptotrichia, Moraxella, Mycobacterium, Myroides, Neisseria, Nocardia, Paenibacillus, Prevotella, Pseudomonas, Pseudonocardia, Psychrobacter, Rhodococcus, Rickettsia, Saccharomonospora, Sphingomonas, Stenotrophomonas, Streptococcus, and Treponema.