CPC A61K 35/17 (2013.01) [C07K 14/7051 (2013.01); C12N 9/22 (2013.01); C12N 15/86 (2013.01); C12N 2750/14143 (2013.01)] | 5 Claims |
1. An engineered meganuclease that binds and cleaves a recognition sequence consisting of SEQ ID NO: 5 within a human T cell receptor (TCR) alpha constant region gene, wherein said engineered meganuclease comprises an amino acid sequence of SEQ ID NO: 7.
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