CPC A61K 35/17 (2013.01) [C07K 14/7155 (2013.01); C07K 16/2818 (2013.01); C07K 16/30 (2013.01); C12N 15/67 (2013.01); A61K 38/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01)] | 33 Claims |
1. A PD-1 chimeric cytokine receptor comprising:
a. a PD-1 ectodomain or an antigen binding domain of an anti-PD-L1 or an anti-PD-L2 antibody;
b. a transmembrane domain;
c. a Janus Kinase (JAK)-binding domain; and
d. a recruiting domain comprising a STAT-recruiting domain from IL2Rb,
wherein the transmembrane domain and JAK-binding domain comprise SEQ ID NO: 40, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, or SEQ ID NO: 27.
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