US 11,786,528 B2
Pyrazolopyrimidine compounds as adenosine receptor antagonists
Andrew Simon Bell, Dundee (GB); Adrian Michael Schreyer, Dundee (GB); and Stephanie Versluys, Toulouse (FR)
Assigned to EXSCIENTIA LTD., Dundee (GB); and EVOTEC INTERNATIONAL GMBH, Hamburg (DE)
Appl. No. 15/734,074
Filed by EXSCIENTIA LTD., Dundee (GB); and EVOTEC INTERNATIONAL GMBH, Hamburg (DE)
PCT Filed Jun. 4, 2019, PCT No. PCT/EP2019/064450
§ 371(c)(1), (2) Date Dec. 1, 2020,
PCT Pub. No. WO2019/233994, PCT Pub. Date Dec. 12, 2019.
Claims priority of application No. 18290061 (EP), filed on Jun. 4, 2018.
Prior Publication US 2021/0251995 A1, Aug. 19, 2021
Int. Cl. C07D 487/04 (2006.01); A61P 35/00 (2006.01); A61K 31/519 (2006.01); G01N 33/566 (2006.01)
CPC A61K 31/519 (2013.01) [A61P 35/00 (2018.01); C07D 487/04 (2013.01); G01N 33/566 (2013.01)] 28 Claims
 
1. A compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate,

OG Complex Work Unit Chemistry
wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle comprising 1, 2 or 3 heteroatoms independently selected from the group consisting of N, S and O, wherein said phenyl is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of halogen, OH, C1-8alkyl, C1-8aklyl substituted with 1, 2 or 3 halogens or OH groups, OC1-8alkyl, and OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, and wherein said 5- or 6-membered aromatic heterocycle is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of halogen, OH, C1-8alkyl, C1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, OC1-8alkyl, and OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups; and
R2 is an optionally substituted 5- or 6-membered aromatic heterocycle comprising 2 or 3 heteroatoms independently selected from the group consisting of N, S and O, wherein said 5- or 6-membered aromatic heterocycle is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of C1-3alkyl and C1-3alkyl substituted with 1, 2 or 3 halogens;
with the proviso that the compound is not selected from the group consisting of

OG Complex Work Unit Chemistry