CPC A61K 31/519 (2013.01) [A61P 35/00 (2018.01); C07D 487/04 (2013.01); G01N 33/566 (2013.01)] | 28 Claims |
1. A compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate,
wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle comprising 1, 2 or 3 heteroatoms independently selected from the group consisting of N, S and O, wherein said phenyl is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of halogen, OH, C1-8alkyl, C1-8aklyl substituted with 1, 2 or 3 halogens or OH groups, OC1-8alkyl, and OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, and wherein said 5- or 6-membered aromatic heterocycle is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of halogen, OH, C1-8alkyl, C1-8alkyl substituted with 1, 2 or 3 halogens or OH groups, OC1-8alkyl, and OC1-8alkyl substituted with 1, 2 or 3 halogens or OH groups; and
R2 is an optionally substituted 5- or 6-membered aromatic heterocycle comprising 2 or 3 heteroatoms independently selected from the group consisting of N, S and O, wherein said 5- or 6-membered aromatic heterocycle is optionally substituted with 1, 2 or 3 substituents, each substituent being independently selected from the group consisting of C1-3alkyl and C1-3alkyl substituted with 1, 2 or 3 halogens;
with the proviso that the compound is not selected from the group consisting of
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