CPC A61K 9/1075 (2013.01) [A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61P 35/00 (2018.01); B82Y 5/00 (2013.01)] | 13 Claims |
1. A micelle, comprising:
(i) a block copolymer, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, the block copolymer comprising:
wherein:
R1 and R2 are each independently hydrogen or an optionally substituted C1-C6 alkyl;
R3 and R4 are each independently an optionally substituted C1-C6 alkyl, C3-C10 cycloalkyl or aryl;
or R3 and R4 are taken together with the corresponding nitrogen to which they are attached form an optionally substituted 5 to 7-membered ring;
n1 is an integer from 10-200;
x1 is an integer from 20-300;
y1 is an integer from 0-10;
X is a halogen, —OH, or —C(O)OH; and
R5 is hydrogen or a fluorescent dye; and
(ii) a therapeutic agent encapsulated by the block copolymer, wherein the therapeutic agent is a monocarboxylate transport inhibitor having the formula:
or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
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