US 11,786,454 B2
Compositions for topical treatment of microbial infections
Patrick M. Schlievert, Iowa City, IA (US)
Assigned to Hennepin Life Sciences, LLC, Plymouth, MN (US)
Filed by Hennepin Life Sciences, Plymouth, MN (US)
Filed on Feb. 29, 2016, as Appl. No. 15/56,239.
Application 15/056,239 is a division of application No. 13/866,722, filed on Apr. 19, 2013, granted, now 9,724,295.
Claims priority of provisional application 61/636,203, filed on Apr. 20, 2012.
Claims priority of provisional application 61/650,755, filed on May 23, 2012.
Prior Publication US 2016/0175244 A1, Jun. 23, 2016
Int. Cl. A61K 9/00 (2006.01); A61K 31/23 (2006.01); A61K 45/06 (2006.01); A61K 9/06 (2006.01); A61K 47/38 (2006.01); A61K 31/04 (2006.01); A61K 31/195 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/44 (2017.01)
CPC A61K 9/0014 (2013.01) [A61K 9/06 (2013.01); A61K 31/04 (2013.01); A61K 31/195 (2013.01); A61K 31/23 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/38 (2013.01); A61K 47/44 (2013.01); Y02A 50/30 (2018.01)] 10 Claims
 
1. A method of treating or preventing a gram-positive bacterial skin infection, a gram-positive bacterial infection of a wound, or a gram-positive bacterial infection of surgical incision cite in a subject in need thereof, the method comprising the step of topically administering an effective amount of a composition comprising
GML and a non-aqueous gel comprised of a combination of propylene glycol, polyethylene glycol, and cellulose derivative and the non-aqueous gel having a pH from about 4.0 to about 4.5, wherein the non-aqueous gel is at a concentration of about 10% to about 25% of the composition,
to treat or prevent the gram-positive bacterial skin infection, the gram-positive bacterial infection of a wound, or the gram-positive bacterial infection of surgical incision cite in the subject,
wherein GML is present at a concentration of about 10 μg/mL to about 100 mg/mL; and
wherein the GML is the isomer of GML with lauric acid in the 2-position of glycerol.