US 11,786,218 B2
Burst ultrasound reconstruction with signal templates and related methods and systems
Daniel P. Sawyer, Pasadena, CA (US); Arash Farhadi, Pasadena, CA (US); Avinoam D. Bar-Zion, Pasadena, CA (US); and Mikhail Shapiro, Pasadena, CA (US)
Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed by CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US)
Filed on Jan. 7, 2020, as Appl. No. 16/736,581.
Claims priority of provisional application 62/895,553, filed on Sep. 4, 2019.
Claims priority of provisional application 62/825,612, filed on Mar. 28, 2019.
Claims priority of provisional application 62/789,295, filed on Jan. 7, 2019.
Prior Publication US 2020/0237346 A1, Jul. 30, 2020
Int. Cl. A61B 8/08 (2006.01)
CPC A61B 8/5207 (2013.01) [A61B 8/481 (2013.01); A61B 8/5246 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method of ultrasound imaging to be used on a target site contrasted with gas vesicles (GVs) having an acoustic collapse pressure threshold, the method comprising:
applying ultrasound to the target site at a peak positive pressure less than the acoustic collapse pressure threshold;
increasing peak positive pressure (PPP) to above the selective acoustic collapse pressure value threshold as a step function;
imaging the target site in successive frames during the increasing;
extracting a time-series vector for each of at least one pixel of the successive frames; and
detecting from the time-series vectors a transient signal from, due to the increasing PPP, fluid displacement from collapsing of the GVs or cavitating bubbles released from the GVs, the detecting being in a time domain of the successive frames, the transient signal providing an increase in contrast signal in the ultrasound imaging.