US 11,786,168 B2
Epidermal sensing systems for optical readout, visualization and analysis of biofluids
John A. Rogers, Wilmette, IL (US); Johnathan T. Reeder, Plano, TX (US); Amay J. Bandodkar, Evanston, IL (US); Sungbong Kim, Champaign, IL (US); Yurina Sekine, Evanston, IL (US); Jungil Choi, Chicago, IL (US); Tyler R. Ray, Evanston, IL (US); Aurelie Hourlier-Fargette, Evanston, IL (US); Philipp Gutruf, Evanston, IL (US); Kun Hyuck Lee, Evanston, IL (US); and Milan Raj, Evanston, IL (US)
Assigned to NORTHWESTERN UNIVERSITY, Evanston, IL (US); and THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
Appl. No. 16/616,898
Filed by NORTHWESTERN UNIVERSITY, Evanston, IL (US); and THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US)
PCT Filed Jun. 1, 2018, PCT No. PCT/US2018/035738
§ 371(c)(1), (2) Date Nov. 25, 2019,
PCT Pub. No. WO2018/223090, PCT Pub. Date Dec. 6, 2018.
Claims priority of provisional application 62/514,468, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,520, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,374, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,455, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,546, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,515, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,559, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,489, filed on Jun. 2, 2017.
Claims priority of provisional application 62/514,436, filed on Jun. 2, 2017.
Prior Publication US 2021/0145352 A1, May 20, 2021
Int. Cl. A61B 5/00 (2006.01); A61B 5/1455 (2006.01); A61B 5/1486 (2006.01); A61B 5/145 (2006.01); A61B 5/1477 (2006.01); A61B 5/01 (2006.01); A61B 5/103 (2006.01)
CPC A61B 5/4266 (2013.01) [A61B 5/0022 (2013.01); A61B 5/01 (2013.01); A61B 5/1032 (2013.01); A61B 5/1455 (2013.01); A61B 5/1477 (2013.01); A61B 5/1486 (2013.01); A61B 5/14517 (2013.01); A61B 5/14532 (2013.01); A61B 5/14539 (2013.01); A61B 5/14546 (2013.01); A61B 2562/0242 (2013.01); A61B 2562/0276 (2013.01); A61B 2562/164 (2013.01)] 41 Claims
OG exemplary drawing
 
1. A microfluidic system for monitoring a biofluid, comprising:
a flexible substrate;
a microfluidic network at least partially embedded in or supported by the substrate;
a biofluid inlet fluidically connected to said microfluidic network to transport a biofluid from a skin surface to said microfluidic network;
an optical sensor supported by the substrate and configured to sense one or more parameters of said biofluid or a component thereof, said optical sensor including one or more integrated optical structures, wherein said optical sensor comprises a colorimetric sensor, and
a near-field communication (NFC) electronics module operably connected to support wireless power delivery, wireless data transmission or both to said system.