US 11,786,121 B2
System and method for measuring cardiorespiratory response
Richard Wilson, Calgary (CA); Nicholas Jendzjowsky, Calgary (CA); Robert Herman, Calgary (CA); Willis Tsai, Calgary (CA); Fiona Costello, Calgary (CA); and Craig Steinback, Edmonton (CA)
Appl. No. 16/609,893
Filed by UTI LIMITED PARTNERSHIP, Calgary (CA); and THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, Edmonton (CA)
PCT Filed May 3, 2018, PCT No. PCT/CA2018/050526
§ 371(c)(1), (2) Date Oct. 31, 2019,
PCT Pub. No. WO2018/201253, PCT Pub. Date Nov. 8, 2018.
Claims priority of provisional application 62/500,837, filed on May 3, 2017.
Prior Publication US 2020/0196862 A1, Jun. 25, 2020
Int. Cl. A61B 3/12 (2006.01); A61B 3/00 (2006.01); A61B 5/00 (2006.01); A61B 3/10 (2006.01)
CPC A61B 3/1241 (2013.01) [A61B 3/0025 (2013.01); A61B 3/102 (2013.01); A61B 3/1233 (2013.01); A61B 5/4035 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A system for determining differences in sympathetic nervous system activity in a first human subject, the system comprising:
an imaging device for imaging at least one portion of a human eye of said first human subject, said imaging device producing at least one image of said at least one portion of said human eye;
a data storage device for storing baseline data from at least one previously obtained baseline image of the human eye of said first human subject and for storing said at least one image;
a data processor for processing said at least one image and for extracting data from said at least one image;
wherein
said data storage device stores said at least one image from said imaging device;
said data processor compares data extracted from said at least one image with said baseline data;
said data extracted from said at least one image is a pixel density or a voxel density of said at least one image;
said baseline data is pixel density or voxel density of said at least one previously obtained baseline image;
prior to said data being extracted from said at least one image, said at least one image undergoes color switching, a degree of said color switching for said at least one image being determined by said data processor based on said baseline data, such that, after said color switching, said data extracted from said at least one image is suitable for comparison with said baseline data;
said at least one portion comprises choroid vasculature of said human eye; and
said pixel density or said voxel density of said at least one image is indicative of vascular perfusion density in said choroid vasculature such that said pixel density or said voxel density of said at least one image is directly related to said sympathetic nervous system activity.