US 11,754,561 B2
Functionalized biochips for SPR-MS coupling
Régis Daniel, Issy les Moulineaux (FR); Florence Gonnet, Villiers sur Orge (FR); William Buchmann, Sainte Genevieve des Bois (FR); Sophie Bellon, Paris (FR); Nathalie Jarroux, Ballainvilliers (FR); and Marielle Anger-Leroy, Les Ulis (FR)
Assigned to GENOPTICS, Orsay (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and UNIVERSITE D'EVRY VAL D'ESSONNE, Evry (FR)
Filed by GENOPTICS, Orsay (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and UNIVERSITE D'EVRY VAL D'ESSONNE, Evry (FR)
Filed on May 9, 2016, as Appl. No. 15/149,833.
Application 15/149,833 is a continuation of application No. 12/734,854, abandoned, previously published as PCT/FR2008/052149, filed on Nov. 27, 2008.
Claims priority of application No. 0759351 (FR), filed on Nov. 27, 2007.
Prior Publication US 2016/0377610 A1, Dec. 29, 2016
Int. Cl. G01N 33/543 (2006.01); G01N 21/552 (2014.01); G01N 33/553 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/54373 (2013.01) [G01N 21/554 (2013.01); G01N 33/54353 (2013.01); G01N 33/553 (2013.01); G01N 33/6851 (2013.01); G01N 2560/00 (2013.01); G01N 2570/00 (2013.01); Y10T 436/24 (2015.01)] 21 Claims
OG exemplary drawing
 
1. A method for functionalizing the metal face of a glass support for analysis by surface plasmon resonance, said method comprising grafting a self-assembled monolayer of poly(ethylene oxide) directly onto the metal face of said support,
in which the metal of the metal face is gold, and
in which the poly(ethylene oxide) is a compound of formula (I)
S—(CH2)n—(O—CH2—CH2)x-D  (I)
in which:
n is equal to 1 or 2;
x is an integer between 5 and 16; and
D is a group able to bind biomolecules or is a group that may be transformed in a group able to bind biomolecules.