US 11,753,661 B2
Process for the biological production of methacrylic acid and derivatives thereof
Graham Ronald Eastham, Redcar (GB); Gill Stephens, Nottingham (GB); and Andrew Yiakoumetti, Nottingham (GB)
Assigned to Mitsubishi Chemical UK Limited, Billingham (GB)
Filed by Mitsubishi Chemical UK Limited, Billingham (GB)
Filed on Apr. 14, 2022, as Appl. No. 17/720,739.
Application 17/506,130 is a division of application No. 16/881,060, filed on May 22, 2020, granted, now 11,248,243, issued on Feb. 15, 2022.
Application 17/720,739 is a continuation of application No. 17/506,130, filed on Oct. 20, 2021.
Application 16/881,060 is a continuation of application No. 15/574,961, granted, now 10,704,063, issued on Jul. 7, 2020, previously published as PCT/GB2016/051438, filed on May 18, 2016.
Claims priority of application No. 1508582 (GB), filed on May 19, 2015; and application No. 1517545 (GB), filed on Oct. 5, 2015.
Prior Publication US 2022/0372527 A1, Nov. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12P 7/40 (2006.01); C12N 9/02 (2006.01); C12N 9/16 (2006.01); C12P 7/62 (2022.01); C12P 5/02 (2006.01); C07C 67/00 (2006.01); C08F 120/06 (2006.01); C08F 120/14 (2006.01); C12N 9/10 (2006.01)
CPC C12P 7/40 (2013.01) [C07C 67/00 (2013.01); C08F 120/06 (2013.01); C08F 120/14 (2013.01); C12N 9/001 (2013.01); C12N 9/1029 (2013.01); C12N 9/16 (2013.01); C12P 5/026 (2013.01); C12P 7/62 (2013.01); C12Y 103/03006 (2013.01); C12Y 203/01084 (2013.01); C12Y 301/02023 (2013.01); Y02E 50/30 (2013.01)] 18 Claims
 
1. A process of producing methacrylic acid and/or derivatives thereof comprising the following steps:
(a) biologically converting isobutyryl-CoA into methacrylyl-CoA by the action of a short chain acyl-CoA oxidase from Arthrobacter nicotianae; and
(b) converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof.