CPC C12N 9/52 (2013.01) [A61K 39/07 (2013.01); A61K 39/08 (2013.01); A61P 29/00 (2018.01); C07K 14/32 (2013.01); C07K 14/33 (2013.01); C12N 9/50 (2013.01); C07K 2319/01 (2013.01); C07K 2319/55 (2013.01)] | 30 Claims |
1. A method for treatment of pain, the method comprising administering to a subject in need thereof a composition comprising a nucleic acid that encodes a fusion protein, wherein the fusion protein comprises:
a botulinum neurotoxin (BTx) moiety, wherein the BTx moiety comprises (i) a BTx enzymatic moiety capable of cleaving a SNARE protein and (ii) a BTx translocation domain, and
a targeting moiety comprising a C-terminal receptor-binding domain of an anthrax toxin protective antigen (PA), wherein the C-terminal receptor-binding domain of PA comprises a PAd4 domain,
wherein the BTx moiety and the targeting moiety are linked or fused together.
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