CPC C12N 9/2465 (2013.01) [A61K 48/005 (2013.01); C12N 15/09 (2013.01); C12Y 302/0102 (2013.01); C12N 2510/02 (2013.01)] | 19 Claims |
1. A method for metabolizing, degrading, removing, or decreasing glycogen in tissue, muscle, muscle fiber, muscle cells, lysosomes, organelles, cellular compartments, or cytoplasm of a cell in a subject in need thereof, wherein the method comprises administering to the subject a composition comprising recombinant human acid alpha-glucosidase (rhGAA) produced from Chinese hamster ovary (CHO) cells, wherein 40%-60% of the N-glycans on the rhGAA are complex type N-glycans and the rhGAA comprises 3.0-6.0 mol mannose-6-phosphate (M6P) per mol rhGAA.
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