CPC C08B 3/16 (2013.01) [B01F 27/1122 (2022.01); B01F 27/1125 (2022.01); B01F 27/1145 (2022.01)] | 2 Claims |
1. A method for producing hydroxypropyl methyl cellulose acetate succinate comprising:
an esterification step of reacting hydroxypropyl methyl cellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing hydroxypropyl methyl cellulose acetate succinate;
a precipitation step of precipitating the hydroxypropyl methyl cellulose acetate succinate by mixing the reaction product solution with water to obtain a suspension of the precipitated hydroxypropyl methyl cellulose acetate succinate; and
a washing and recovering step of washing the hydroxypropyl methyl cellulose acetate succinate in the suspension and recovering the washed hydroxypropyl methyl cellulose acetate succinate.
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