CPC C07K 16/2866 (2013.01) [C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01)] | 13 Claims |
1. An isolated anti-CD115 antibody, or an antigen-binding fragment thereof, comprising:
(a)(i) a heavy chain variable region (VH) comprising a heavy chain variable complementarity determining region 1 (HCDR1) comprising SEQ ID NO: 445; a HCDR2 comprising SEQ ID NO: 877; and a HCDR3 comprising SEQ ID NO: 1309; and (ii) a light chain variable region (VL) comprising a light chain variable complementarity determining region 1 (LCDR1) comprising SEQ ID NO: 661; a LCDR2 comprising SEQ ID NO: 1093; and a LCDR3 comprising SEQ ID NO: 1525,
(b)(i) a heavy chain variable region comprising a VHCDR1 comprising SEQ ID NO: 481, a VHCDR2 comprising SEQ ID NO: 913, and a VHCDR3 comprising SEQ ID NO: 1345 and (ii) a light chain variable region comprising a VLCDR1 comprising SEQ ID NO: 697, a VLCDR2 comprising SEQ ID NO: 1129, and a VLCDR3 comprising SEQ ID NO: 1561, or
(c)(i) a heavy chain variable region comprising a VHCDR1 comprising SEQ ID NO: 533, a VHCDR2 comprising SEQ ID NO: 965, and a VHCDR3 comprising SEQ ID NO: 1397 and (ii) a light chain variable region comprising a VLCDR1 comprising SEQ ID NO: 749, a VLCDR2 comprising SEQ ID NO: 1181, and a VLCDR3 comprising SEQ ID NO: 1613.
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