US 11,753,478 B2
Anti-CD115 antibodies
John Lippincott, San Diego, CA (US); and Dana Duey, San Diego, CA (US)
Assigned to ABLEXIS, LLC, San Diego, CA (US)
Filed by Ablexis, LLC, San Diego, CA (US)
Filed on Jun. 16, 2020, as Appl. No. 16/902,940.
Application 16/902,940 is a division of application No. 15/760,322, granted, now 10,759,861, previously published as PCT/US2016/052063, filed on Sep. 16, 2016.
Claims priority of provisional application 62/220,147, filed on Sep. 17, 2015.
Claims priority of provisional application 62/219,578, filed on Sep. 16, 2015.
Prior Publication US 2020/0308291 A1, Oct. 1, 2020
Int. Cl. C07K 16/28 (2006.01)
CPC C07K 16/2866 (2013.01) [C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01)] 13 Claims
 
1. An isolated anti-CD115 antibody, or an antigen-binding fragment thereof, comprising:
(a)(i) a heavy chain variable region (VH) comprising a heavy chain variable complementarity determining region 1 (HCDR1) comprising SEQ ID NO: 445; a HCDR2 comprising SEQ ID NO: 877; and a HCDR3 comprising SEQ ID NO: 1309; and (ii) a light chain variable region (VL) comprising a light chain variable complementarity determining region 1 (LCDR1) comprising SEQ ID NO: 661; a LCDR2 comprising SEQ ID NO: 1093; and a LCDR3 comprising SEQ ID NO: 1525,
(b)(i) a heavy chain variable region comprising a VHCDR1 comprising SEQ ID NO: 481, a VHCDR2 comprising SEQ ID NO: 913, and a VHCDR3 comprising SEQ ID NO: 1345 and (ii) a light chain variable region comprising a VLCDR1 comprising SEQ ID NO: 697, a VLCDR2 comprising SEQ ID NO: 1129, and a VLCDR3 comprising SEQ ID NO: 1561, or
(c)(i) a heavy chain variable region comprising a VHCDR1 comprising SEQ ID NO: 533, a VHCDR2 comprising SEQ ID NO: 965, and a VHCDR3 comprising SEQ ID NO: 1397 and (ii) a light chain variable region comprising a VLCDR1 comprising SEQ ID NO: 749, a VLCDR2 comprising SEQ ID NO: 1181, and a VLCDR3 comprising SEQ ID NO: 1613.