CPC C07K 14/70521 (2013.01) [A61K 35/17 (2013.01); A61K 47/65 (2017.08); A61P 19/02 (2018.01); C07K 14/7051 (2013.01); C12N 5/0637 (2013.01); C12N 15/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01)] | 31 Claims |
1. A variant CTLA-4 polypeptide, comprising an IgV domain or a specific binding fragment thereof, wherein the variant CTLA-4 polypeptide comprises one or more amino acid modifications in an unmodified CTLA-4 polypeptide or a specific binding fragment thereof corresponding to position(s) selected from among 29, 53, 56, 58, 82, 87, and 98, with reference to positions set forth in SEQ ID NO:2 and wherein the sequence includes L63P and Y105L.
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