CPC C07K 14/7051 (2013.01) [A61K 35/17 (2013.01); A61P 19/02 (2018.01); A61P 37/06 (2018.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 16/18 (2013.01); C07K 16/36 (2013.01); C12N 5/0636 (2013.01); C12N 15/625 (2013.01); C12N 15/85 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01); C07K 2317/622 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/998 (2013.01)] | 30 Claims |
1. A chimeric antigen receptor (CAR) comprising an antigen-binding domain, a hinge domain, a transmembrane domain, one or more co-stimulatory domains, and an intracellular signaling domain, wherein the antigen binding domain specifically binds to three or more different citrullinated proteins or citrullinated fragments thereof, and comprises complementarity-determining regions (CDRs) from VH and VL domains of SEQ ID NO:1 and SEQ ID NO:4.
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