US 11,753,454 B2
IL-15 and IL-15R\alpha sushi domain based immunocytokines
Sebastien Daniel Morisseau, Donges (FR); Geraldine Teppaz, Nantes (FR); Yannick Laurent Joseph Jacques, Nantes (FR); Bruno Gilbert Marc Robert, Valflaunes (FR); Guy Luc Michel De Martynoff, Mont-St-Guibert (BE); and David Bechard, Saint-Etienne de Montluc (FR)
Assigned to Cytune Pharma, Nantes (FR); and INSERM (Institut National de la Santé et de la Recherche Médicale), Paris (FR)
Filed by Cytune Pharma, Nantes (FR); and INSERM (Institut National De La Santé Et De La Recherche Medicale), Paris (FR)
Filed on Oct. 12, 2020, as Appl. No. 17/68,628.
Application 17/068,628 is a division of application No. 16/012,174, filed on Jun. 19, 2018, granted, now 10,899,816.
Application 16/012,174 is a continuation of application No. 15/214,032, filed on Jul. 19, 2016, granted, now 10,626,155, issued on Apr. 21, 2020.
Application 15/214,032 is a continuation of application No. 14/129,188, abandoned, previously published as PCT/EP2012/002650, filed on Jun. 22, 2012.
Claims priority of application No. 1358005 (EP), filed on Jun. 24, 2011.
Prior Publication US 2021/0147503 A1, May 20, 2021
Int. Cl. C07K 14/54 (2006.01); A61K 38/20 (2006.01); C07K 14/715 (2006.01); C07K 16/32 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 14/5443 (2013.01) [A61K 38/2086 (2013.01); C07K 14/7155 (2013.01); C07K 16/32 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 16/2887 (2013.01); C07K 16/3084 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01); C07K 2319/31 (2013.01); C07K 2319/32 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01)] 11 Claims
 
1. An isolated nucleic acid encoding a receptor-linker-interleukin (RLI) conjugate comprising an amino acid sequence represented by SEQ ID NO: 17.