CPC C07J 63/008 (2013.01) [A61K 31/56 (2013.01); A61K 31/58 (2013.01); A61P 3/04 (2018.01)] | 14 Claims |
1. A compound of Formula (I):
or a pharmaceutically acceptable salt or prodrug thereof, wherein
the dotted lines between C1 and C2, C2 and R3, C3 and R4, C5 and C6, C5 and C7, C1 and C6, and C3 and C4 indicate that a single or double bond may be present, as valence permits;
R1 is —NHR5, —NR5R5, —NHCOR5, —NR5COR5, —NHSO2R5, or —NR5SO2R5;
R2 is —H, —CH3, —SCH(CH3)2, —SC(═O)CH3, —SC(═O)R5, —SCH2CH2OCOCH3, —SR5, —SOR5, —SOOR5, —SCONR5R5,
R3 is —OCOCH3, —OCOOCH2CH3, —OR7, —R7, or —NR5R5 when a double bond is present between C1 and C2, C3 and C4, and C5 and C6
R4 is —OCOCH3, —OCOOCH2CH3, —OR7, —R7, or —NR5R5 when a double bond is present between C1 and C2, C3 and C4, and C5 and C6;
R3 is O when R4 is O and a double bond is present between C2 and R3 and C3 and R4;
R4 is —OCH3, —OP(═O)(OCH3)2, —OH, —OCOOCH2CH3, —OCONHCH2CH3, —OCOOCH(CH3)2, —OR7, —R7, or —NR5R5 when R3 is O and a double bond is present between C2 and R3;
R5 is independently selected for each occurrence from hydrogen, an alkyl, cycloalkyl, and aryl; and
R7 is hydrogen, methyl, or ethyl.
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