US 11,753,435 B2
Process
Stephen Geytenbeek, Clayton (AU); Andrew Stirling, Clayton (AU); and Paul David Gavin, Clayton (AU)
Assigned to Avecho Biotechnology Limited, Victoria (AU)
Filed by Avecho Biotechnology Limited, Clayton (AU)
Filed on Dec. 15, 2021, as Appl. No. 17/552,188.
Application 17/552,188 is a continuation of application No. 16/470,943, abandoned, previously published as PCT/AU2017/051381, filed on Dec. 13, 2017.
Claims priority of application No. 2016905298 (AU), filed on Dec. 21, 2016.
Prior Publication US 2022/0106353 A1, Apr. 7, 2022
Int. Cl. C07J 51/00 (2006.01); C07F 9/09 (2006.01)
CPC C07J 51/00 (2013.01) [C07F 9/09 (2013.01); C07F 9/095 (2013.01)] 7 Claims
 
1. A process for phosphorylating tocopherol, comprising the steps of:
(a) mixing the tocopherol and P4O10 until the mixture achieves an exothermic reaction temperature, said temperature being the temperature at which the chemical reaction between the tocopherol and P4O10 commences to release heat into the mixture;
(b) allowing the reaction mixture of step (a) to react until the exothermic reaction is complete, wherein the exothermic reaction is complete when the temperature of the mixture comprising the chemical reaction between the tocopherol and P4O10 begins to fall;
(c) cooling the reaction mixture of step (b) to at least 80° C.; and
(d) hydrolysing the reaction mixture of step (c), wherein hydrolysis is conducted for 30 to 90 minutes.