CPC C07D 487/04 (2013.01) [C07D 519/00 (2013.01)] | 19 Claims |
1. A compound having Formula (I′):
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
X is N;
Y is C1-C6alkyl, C3-C6cycloalkyl, C2-C9heterocycloalkyl, C6-C10aryl, or C2-C9heteroaryl, wherein the C1-C6alkyl, C3-C6cycloalkyl, C2-C9heterocycloalkyl, C6-C10aryl, or C2-C9heteroaryl is optionally substituted by 1, 2, 3, or 4 independently selected R7 substituents; or
Y is
L1 is a bond, —CH2NR9—, —C(O)—, —NR9—, —NR9CH2—, or —O—;
R1 is C3-C6cycloalkyl, wherein the C3-C6cycloalkyl is substituted by 1, 2, or 3 independently selected R13 substituents;
R2 is hydrogen, deuterium, C1-C6alkyl, or C1-C6deuteroalkyl;
R3 is hydrogen, deuterium, C1-C6alkyl, or C1-C6deuteroalkyl;
R4 is hydrogen, deuterium, C1-C6alkyl, or C1-C6deuteroalkyl;
R5 is hydrogen or C1-C6alkyl;
R6 is hydrogen, deuterium, C1-C6alkyl, or C1-C6deuteroalkyl;
each R7 is independently deuterium, halogen, —CN, C1-C6alkyl, C1-C6deuteroalkyl, C1-C6haloalkyl, C1-C6heteroalkyl, —C(O)R11, —C(O)NR10R10, —C(O)OR10, —NR10R10, —NR10C(O)R11, —NR10S(O)2R11, —OR10, ═O, —S(O)2R11, —S(O)2NR10R10, C3-C6cycloalkyl, C2-C9heterocycloalkyl, C6-C10aryl, or C2-C9heteroaryl, wherein each C3-C6cycloalkyl, C2-C9heterocycloalkyl, C6-C10aryl, and C2-C9heteroaryl is optionally and independently substituted by 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C6alkyl, C1-C6haloalkyl, —C(O)NR12R12, —C(O)OR12, —NR12R12, —OR12, C2-C9heterocycloalkyl, and C2-C9heteroaryl; or two R7, together with the carbon atom(s) to which they are attached, form a 4-, 5-, or 6-membered cycloalkyl or a 5-, 6-, or 7-membered heterocycloalkyl;
R8 is hydrogen, deuterium, halogen, C1-C6alkyl, or C1-C6deuteroalkyl;
R9 is hydrogen or C1-C6alkyl;
each R10 is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6heteroalkyl, or phenyl, wherein each phenyl is optionally and independently substituted by 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C6alkyl, C1-C6haloalkyl, —C(O)NR12R12, —C(O)OR12, —NR12R12, —OR12, C2-C9heterocycloalkyl, and C2-C9heteroaryl;
each R11 is independently C1-C6alkyl or C1-C6heteroalkyl;
each R12 is independently hydrogen, C1-C6alkyl, or C1-C6haloalkyl;
each R13 is independently halogen, —CN, C1-C6alkyl, C1-C6deuteroalkyl, C1-C6haloalkyl, C1-C6heteroalkyl, —C(O)R11, —C(O)NR10R10, —C(O)OR10, —NR10R10, —NR10C(O)R11, —NR10S(O)2R11, —OR10, ═O, —S(O)2R11, —S(O)2NR10R10, C3-C6cycloalkyl, C2-C9heterocycloalkyl, C6-C10aryl, or C2-C9heteroaryl, wherein each C3-C6cycloalkyl, C2-C9heterocycloalkyl, C6-C10aryl, and C2-C9heteroaryl is optionally and independently substituted by 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C6alkyl, C1-C6haloalkyl, —C(O)NR12R12, —C(O)OR12, —NR12R12, —OR12, C2-C9heterocycloalkyl, and C2-C9heteroaryl; and
n is 0, 1, 2, 3, or 4.
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16. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of claim 1, or a pharmaceutically acceptable salt or stereoisomer thereof.
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