US 11,753,386 B2
Processes for preparing a MDM2 inhibitor
Sebastien Caille, Thousand Oaks, CA (US); Michael Corbett, Thousand Oaks, CA (US); and Austin Smith, Thousand Oaks, CA (US)
Assigned to Amgen, Inc., Thousand Oaks, CA (US)
Appl. No. 17/272,031
Filed by Amgen, Inc., Thousand Oaks, CA (US)
PCT Filed Aug. 30, 2019, PCT No. PCT/US2019/049087
§ 371(c)(1), (2) Date Feb. 26, 2021,
PCT Pub. No. WO2020/047424, PCT Pub. Date Mar. 5, 2020.
Claims priority of provisional application 62/725,574, filed on Aug. 31, 2018.
Prior Publication US 2021/0347743 A1, Nov. 11, 2021
Int. Cl. C07D 263/14 (2006.01); C07D 211/76 (2006.01)
CPC C07D 263/14 (2013.01) [C07D 211/76 (2013.01); C07B 2200/13 (2013.01)] 6 Claims
 
1. A process of preparing compound

OG Complex Work Unit Chemistry
the process comprising reacting

OG Complex Work Unit Chemistry
with methoxymethylene-N,N-dimethyliminium methyl sulfate.