US 11,752,348 B2
Systems and methods for closed-loop determination of stimulation parameter settings for an electrical simulation system
David Blum, Boston, MA (US); Sherry Lin, Sherman Oaks, CA (US); Hemant Bokil, Cambridge, MA (US); and Michael A. Moffitt, Solon, OH (US)
Assigned to Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed by Boston Scientific Neuromodulation Corporation, Valencia, CA (US)
Filed on Jan. 21, 2020, as Appl. No. 16/748,161.
Application 16/748,161 is a continuation of application No. 15/783,961, filed on Oct. 13, 2017, granted, now 10,603,498.
Claims priority of provisional application 62/545,819, filed on Aug. 15, 2017.
Claims priority of provisional application 62/408,620, filed on Oct. 14, 2016.
Prior Publication US 2020/0155859 A1, May 21, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/372 (2006.01); A61N 1/36 (2006.01); A61N 1/02 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/37247 (2013.01) [A61N 1/025 (2013.01); A61N 1/36125 (2013.01); A61N 1/36132 (2013.01); A61N 1/36139 (2013.01); A61N 1/0534 (2013.01); A61N 1/0551 (2013.01); A61N 1/37241 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for facilitating programming settings of an implantable pulse generator associated with a patient, the system comprising:
a processor;
a memory; and
control logic, stored in the memory, and configured, when executed by the processor, to perform actions comprising:
a) automatically generating a proposed set of stimulation parameter values using one or more machine learning engines;
b) receiving one or more clinical response values arising from testing of the proposed set of stimulation parameter values by stimulating the patient using the proposed set of stimulation parameter values;
c) predicting one or more therapeutic response values for each of a plurality of sets of untested stimulation parameter values using the one or more machine learning engines and the one or more received clinical response values;
d) selecting, based on at least the one or more predicted therapeutic response values, a revised proposed set of stimulation parameter values from the plurality of sets of untested stimulation parameter values;
e) receiving one or more clinical response values arising from testing of the revised proposed set of stimulation parameter values by stimulating the patient using the revised proposed set of stimulation parameter values; and
f) repeating actions c) to e) until a stop condition has been reached or the one or more received clinical response values indicates a value that corresponds to a therapeutic response indication within a designated tolerance.