CPC A61L 27/54 (2013.01) [A61L 27/20 (2013.01); A61L 27/52 (2013.01); A61L 27/56 (2013.01); C12N 5/0647 (2013.01); A61L 2300/414 (2013.01); A61L 2300/426 (2013.01); A61L 2300/45 (2013.01); A61L 2400/18 (2013.01); A61L 2430/02 (2013.01); C12N 2501/155 (2013.01); C12N 2533/74 (2013.01)] | 22 Claims |
1. A composition comprising:
a porous implantable scaffold material;
one or more growth factors selected from the group consisting of BMP-2, BMP-4, BMP-6, BMP-12 and BMP-14; and
one or more differentiation factors selected from the group consisting of Delta-likel, Delta-1ike3, Delta-like4, Jagged1, and Jagged2, wherein the one or more differentiation factors are attached to the scaffold material and promote the differentiation of hematopoietic stem cells to lymphoid lineage cells; and
wherein the one or more growth factors are encapsulated in the scaffold material and are in an amount effective to promote the ectopic formation of bone tissue on or around the administered scaffold to form an ectopic bone marrow nodule for the infiltration and/or engraftment of hematopoietic stem cells.
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