US 11,752,174 B2
Placental tissue grafts and improved methods of preparing and using the same
John Daniel, Woodstock, GA (US); Randall Spencer, Acworth, GA (US); John Russo, Sarasota, FL (US); and Robert Tofe, Denver, CO (US)
Assigned to MiMedx Group, Inc., Marietta, GA (US)
Filed by MiMedx Group, Inc., Marietta, GA (US)
Filed on Dec. 14, 2020, as Appl. No. 17/120,626.
Application 17/120,626 is a continuation of application No. 15/716,135, filed on Sep. 26, 2017, granted, now 10,874,697.
Application 15/716,135 is a continuation of application No. 14/804,156, filed on Jul. 20, 2015, granted, now 9,789,137, issued on Oct. 17, 2017.
Application 14/804,156 is a continuation of application No. 14/323,964, filed on Jul. 3, 2014, granted, now 9,084,767, issued on Jul. 21, 2015.
Application 14/323,964 is a continuation of application No. 14/262,590, filed on Apr. 25, 2014, granted, now 9,272,003, issued on Mar. 1, 2016.
Application 14/262,590 is a continuation of application No. 14/171,511, filed on Feb. 3, 2014, granted, now 9,533,011, issued on Jan. 3, 2017.
Application 14/171,511 is a continuation of application No. 13/861,305, filed on Apr. 11, 2013, granted, now 8,642,092, issued on Feb. 4, 2014.
Application 13/861,305 is a continuation of application No. 13/765,640, filed on Feb. 12, 2013, granted, now 8,709,493, issued on Apr. 29, 2014.
Application 13/765,640 is a continuation of application No. 13/569,134, filed on Aug. 7, 2012, granted, now 8,409,626, issued on Apr. 2, 2013.
Application 13/569,134 is a continuation of application No. 12/428,908, filed on Apr. 23, 2009, granted, now 8,323,701, issued on Dec. 4, 2012.
Application 12/428,908 is a continuation of application No. 12/206,508, filed on Sep. 8, 2008, granted, now 8,357,403, issued on Jan. 22, 2013.
Claims priority of provisional application 60/989,299, filed on Nov. 20, 2007.
Claims priority of provisional application 60/986,665, filed on Nov. 9, 2007.
Claims priority of provisional application 60/970,780, filed on Sep. 7, 2007.
Prior Publication US 2021/0093672 A1, Apr. 1, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/28 (2015.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61K 35/50 (2015.01); A61K 35/33 (2015.01); A61K 35/19 (2015.01); A61L 27/56 (2006.01)
CPC A61K 35/28 (2013.01) [A61K 35/19 (2013.01); A61K 35/33 (2013.01); A61K 35/50 (2013.01); A61L 27/3604 (2013.01); A61L 27/3683 (2013.01); A61L 27/3834 (2013.01); A61L 27/56 (2013.01); A61F 2210/00 (2013.01); A61F 2230/00 (2013.01); A61L 2430/34 (2013.01); A61L 2430/40 (2013.01); Y10T 156/10 (2015.01); Y10T 156/1039 (2015.01)] 18 Claims
 
1. A tissue graft comprising a first membrane comprising an amnion and at least one additional membrane laminated to the first membrane, wherein the amnion comprises a basement membrane, a compact layer, and a fibroblast layer, and the at least one additional membrane is adjacent to the fibroblast layer;
wherein each additional membrane consists of amnion, chorion, allograft pericardium, allograft acellular dermis, amniotic membrane, Wharton's jelly, purified xenograft Type-1 collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, or any combination thereof; and
wherein said graft comprises a plurality of holes.