	US 11,752,147 B2
	Pharmaceutical composition for the treatment of pain
Beatrice Garrone, Rome (IT); Lucia Durando, Rome (IT); and Fabrizio Calisti, Rome (IT)
Assigned to AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A, Rome (IT)
Filed by AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A., Rome (IT)
Filed on Apr. 15, 2020, as Appl. No. 16/849,545.
Application 16/849,545 is a division of application No. 15/767,543, granted, now 10,786,498, previously published as PCT/EP2016/074835, filed on Oct. 17, 2016.
Claims priority of application No. 15191024 (EP), filed on Oct. 22, 2015.
Prior Publication US 2020/0316060 A1, Oct. 8, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/496 (2006.01); A61K 31/195 (2006.01); A61K 45/06 (2006.01); A61P 25/00 (2006.01)

CPC A61K 31/496 (2013.01) [A61K 31/195 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01)]

8 Claims

1. A method of treating pain, comprising administering to a subject in need thereof trazodone or a salt thereof and gabapentin or a salt or prodrug thereof as the only active agents in a combined effective synergistic amount, wherein said pain is selected from the group consisting of chronic pain, inflammatory pain, and neuropathic pain, wherein said trazodone or a salt thereof is administered in an amount equal to or lower than 0.2 mg/kg and said gabapentin or a salt or prodrug thereof is administered in an amount equal to or lower than 2 mg/kg, and wherein the trazodone or salt thereof and gabapentin or a salt or prodrug thereof weight ratio is from 1:15 to 1:5.