	US 11,752,131 B2
	Methods and pharmaceutical compositions for the treatment of obesity
Fatima-Soraya Taleb, Paris (FR); Ziad Mallat, Paris (FR); and Alain Tedgui, Paris (FR)
Assigned to INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris (FR); and UNIVERSITE PARIS DESCARTES, Paris (FR)
Appl. No. 16/75,204
Filed by INSERM (Institut National de la Sante et de la Recherche Medicale), Paris (FR); and Universite Paris Descartes, Paris (FR)
PCT Filed Feb. 17, 2017, PCT No. PCT/EP2017/053597 § 371(c)(1), (2) Date Aug. 3, 2018, PCT Pub. No. WO2017/140835, PCT Pub. Date Aug. 24, 2017.
Claims priority of application No. 16305190 (EP), filed on Feb. 19, 2016.
Prior Publication US 2018/0369198 A1, Dec. 27, 2018
Int. Cl. A61K 31/405 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 9/12 (2006.01); A61K 31/196 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01)

CPC A61K 31/405 (2013.01) [A61K 31/196 (2013.01); A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61P 9/12 (2018.01)]

6 Claims

1. A method of treating obesity in an obese subject in need thereof, comprising administering to the obese subject a therapeutically effective amount of an indoleamine 2,3-dioxygenase (IDO) inhibitor selected from the group consisting of β-(3-benzofuranyl)-alanine, β-(3-benzo(b)thienyl)-alanine, 6-nitro-tryptophan, 6-fluoro-tryptophan, 4-methyl-tryptophan, 5-methyl tryptophan, 6-methyl-tryptophan, 5-methoxy-tryptophan, 5-hydroxy-tryptophan, 3,3′-diindolylmethane, 5-Br-4-Cl-indoxyl 1,3-diacetate, 9-vinylcarbazole, acemetacin, 5-bromo-tryptophan, 5-bromoindoxyl diacetate, pyrrolidine dithiocarbamate, and 4-phenylimidazole.