CPC A61K 9/0073 (2013.01) [A61K 31/568 (2013.01); A61K 47/38 (2013.01)] | 7 Claims |
1. A powder preparation for nasal administration, comprising: a particulate of a male steroid hormone as an active ingredient and a water-soluble polymer; wherein said particulate has a volume average particle size (D50) in the range of from of 50 μm to 300 μm as measured by a laser diffraction particle size analyzer, and wherein the particle size of each particle is an average of a major axis and a minor axis of the particle; wherein the powder preparation provides a maximum plasma concentration of the male steroid hormone in an adult male after administration to be not more than 15 ng/ml; wherein a weight ratio of the water-soluble polymer to the male steroid hormone is in the range of from 3:1 to 7:1; and wherein said powder preparation is free from a crystalline cellulose and a carboxymethylcellulose sodium.
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