US 11,752,019 B2
Bioactive agent coated medical device and method of coating such a device
John Neilan, Gort (IE); David Murray, Limerick (IE); and James Butler, Aherlow (IE)
Assigned to Cook Medical Technologies LLC, Bloomington, IN (US)
Filed by Cook Medical Technologies LLC, Bloomington, IN (US)
Filed on Nov. 29, 2018, as Appl. No. 16/203,892.
Claims priority of application No. 1819449 (GB), filed on Nov. 29, 2018.
Prior Publication US 2020/0170814 A1, Jun. 4, 2020
Int. Cl. A61F 2/90 (2013.01); A61L 29/16 (2006.01); C22C 19/03 (2006.01); A61L 31/02 (2006.01)
CPC A61F 2/90 (2013.01) [A61L 29/16 (2013.01); A61L 31/022 (2013.01); C22C 19/03 (2013.01); A61L 2300/606 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of coating a medical device having a structure for implantation or disposition inside a patient, the structure including at least one surface for coating, the method including the steps of:
functionalising the at least one surface of the structure by subjecting the at least one surface to acidification by a carboxylic acid to form at least one acid functionalised surface; washing the at least one acid functionalised surface to provide an acid functionalised and cleaned surface, wherein said washing involves rinsing the at least one surface of the medical device in water, wherein said rinsing removes amounts of the carboxylic acid but not all of the carboxylic acid, and wherein said rinsing is conducted until a thickness of a layer of the carboxylic acid is reduced to a minimum thickness achievable by rinsing the at least one surface of the medical device in water and at the end of said rinsing the at least one acid functionalised and cleaned surface exhibits a neutral pH; and applying a bioactive agent layer directly on so as to overlie the at least one acid functionalised and cleaned surface.