US 11,751,767 B2
Structured-light imaging systems and methods for determining sub-diffuse scattering parameters
Stephen Chad Kanick, Lebanon, NH (US); Brian William Pogue, Hanover, NH (US); Keith D. Paulsen, Hanover, NH (US); Jonathan T. Elliott, West Lebanon, NH (US); David M. McClatchy, III, Hanover, NH (US); and Venkataramanan Krishnaswamy, Lebanon, NH (US)
Assigned to The Trustees of Dartmouth College, Hanover, NH (US)
Filed by The Trustees of Dartmouth College, Hanover, NH (US)
Filed on Nov. 4, 2019, as Appl. No. 16/673,165.
Application 16/673,165 is a continuation of application No. 15/013,623, filed on Feb. 2, 2016, granted, now 10,463,256.
Application 15/013,623 is a continuation in part of application No. PCT/US2015/014416, filed on Feb. 4, 2015.
Claims priority of provisional application 62/110,882, filed on Feb. 2, 2015.
Claims priority of provisional application 61/935,803, filed on Feb. 4, 2014.
Prior Publication US 2020/0069187 A1, Mar. 5, 2020
Int. Cl. A61B 5/00 (2006.01)
CPC A61B 5/0075 (2013.01) [A61B 2576/00 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method for determining sub-diffuse scattering parameters of a material, the method operable on a structured light imaging machine, comprising:
illuminating the material with structured light of a plurality of phase shifts, the structured light provided by a structured light illuminator adapted to provide structured light at a plurality of spatial frequencies;
imaging remission by the material of the structured light with a digital camera; and
determining, in an analysis module, from images captured in the step of imaging, sub-diffuse scattering parameters of the material;
wherein the step of illuminating comprises, at a spectral wavelength of the structured light, temporally varying periodic structure of the structured light to produce each of a plurality of spatial frequencies and, for each of the plurality of spatial frequencies, a plurality of spatial phase shifts;
the step of imaging comprising capturing a plurality of images including an image of the remission for each of the plurality of spatial phase shifts associated with each of the plurality of spatial frequencies; and
the step of determining comprising processing the plurality of images to deduce wavelength-specific values of the sub-diffuse scattering parameters;
the step of determining comprises:
generating demodulated images respectively associated with the plurality of spatial frequencies, each of the demodulated images being generated from the plurality of images captured for a respective one of the plurality of spatial frequencies; and
fitting a wavelength dependent model for demodulated remission to the plurality of images, the wavelength dependent model sensitive to (a) the wavelength-specific values of the sub-diffuse scattering parameters and (b) spatial frequency of the periodic structure, to intensities in the demodulated images, to ascertain the wavelength-specific values of the sub-diffuse scattering parameters.