US 11,748,616 B2
Detection of activation in electrograms using neural-network-trained preprocessing of intracardiac electrograms
Eliyahu Ravuna, Kiryat Ata (IL); Natan Sharon Katz, Atlit (IL); Andrey Evgenyevich Kiryasov, Chelyabinsk (RU); Elena Igorevna Kuzhnareva, Moskovskaya obl (RU); and Aleksey Vladimirovich Shovkun, Moscow (RU)
Assigned to Biosense Webster (Israel) Ltd., Yokeam (IL)
Filed by BIOSENSE WEBSTER (ISRAEL) LTD., Yokneam (IL)
Filed on Aug. 12, 2020, as Appl. No. 16/991,766.
Prior Publication US 2022/0051091 A1, Feb. 17, 2022
Int. Cl. G06N 3/08 (2023.01); A61B 5/349 (2021.01); A61B 5/339 (2021.01); A61B 5/287 (2021.01); A61B 5/00 (2006.01); G06N 3/04 (2023.01)
CPC G06N 3/08 (2013.01) [A61B 5/287 (2021.01); A61B 5/339 (2021.01); A61B 5/349 (2021.01); A61B 5/7267 (2013.01); G06N 3/04 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method, comprising:
collecting a plurality of bipolar electrograms and respective unipolar electrograms of patients, the electrograms comprising annotations in which one or more human reviewers have identified and marked a window-of-interest and one or more activation times inside the window-of-interest;
generating, from the electrograms, a ground truth data set for training at least one electrogram-preprocessing step of a Machine Learning (ML) algorithm, wherein the electrogram-preprocessing step comprises specifying coefficients of a set of convolutional kernels and performing one or more convolutions of the electrograms with the set of convolutional kernels and point-by-point multiplication between a bipolar electrogram filtered by one of the convolutional kernels and a respective unipolar electrogram filtered by another one of the convolutional kernels, wherein applying the ML algorithm comprises inputting a multiplication signal resulting from the point-by-point multiplication to the ML algorithm; and
applying the ML algorithm to the electrograms, to at least train the at least one electrogram-preprocessing step, so as to detect an occurrence of an activation in a given bipolar electrogram within the window-of-interest.