US 11,747,421 B2
System and method for quantifying perfusion using a dictionary matching
Vikas Gulani, Shaker Heights, OH (US); Satyam Ghodasara, Cleveland, OH (US); Katherine Wright, Macedonia, OH (US); Nicole Seiberlich, Shaker Heights, OH (US); and Mark A. Griswold, Shaker Heights, OH (US)
Assigned to Case Western Reserve University, Cleveland, OH (US)
Filed by Case Western Reserve University, Cleveland, OH (US)
Filed on May 20, 2019, as Appl. No. 16/416,707.
Claims priority of provisional application 62/673,823, filed on May 18, 2018.
Prior Publication US 2019/0353736 A1, Nov. 21, 2019
Int. Cl. G01R 33/56 (2006.01); G01R 33/563 (2006.01)
CPC G01R 33/5608 (2013.01) [G01R 33/5601 (2013.01); G01R 33/56366 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for generating images of a subject using a magnetic resonance imaging (MRI) system, the method including steps comprising:
performing a predetermined pulse sequence using an MRI system to acquire dynamic contrast-enhanced (DCE) MRI data from a liver of the subject after having delivered a dose of a contrast agent to the subject;
comparing the acquired DCE MRI data to a dictionary to determine perfusion information including at least one perfusion parameter including a distribution volume (DV), wherein the dictionary includes a plurality of entries and each entry includes one or more associated perfusion parameters and comparing the acquired DCE MRI data to the dictionary comprises identifying an entry in the dictionary based on the comparison and assigning the one or more associated perfusion parameters of the identified dictionary entry to the acquired DCE MRI data; and
generating, using the perfusion information including at least one perfusion parameter, a report indicative of perfusion within the liver of the subject;
wherein the dictionary is generated using a dual-input single compartment (DISC) pharmacokinetic model.