CPC G01N 33/86 (2013.01) [G01N 21/82 (2013.01); G01N 33/4905 (2013.01); G01N 35/00693 (2013.01); G01N 2035/0097 (2013.01); G01N 2035/00702 (2013.01); G01N 2333/7454 (2013.01)] | 19 Claims |
1. A blood coagulation analyzing method comprising:
calculating a coagulation time based on data representing a change in an optical detection value of a blood specimen added with a reagent for starting a coagulation reaction, the optical detection value representing amount of light transmitted through the blood specimen added with the reagent;
calculating an index value related to derivatives calculated concerning a coagulation curve represented by the data used in the calculating the coagulation time; and
determining whether an early reaction error has occurred based on a comparison result obtained by comparing the index value to a predetermined threshold, wherein the index value comprises at least one of:
a time period from a first time point at which the reagent is added to a second time point at which a minimum value of a first derivative calculated concerning the coagulation curve is obtained;
an absolute value of the minimum value of the first derivative calculated concerning the coagulation curve;
an integral value of a difference between: the optical detection values in a time period from a third time point at which a predetermined time elapses from the first time point to a fourth time point at which a minimum value of a second derivative calculated concerning the coagulation curve is obtained; and the optical detection value at the third time point; or
a ratio of:
the difference between the optical detection value at the fourth time point and the optical detection value at the third time point; to
a difference between an optical direction value at a fifth time point at which the coagulation reaction is regarded as stopped and the optical detection value at the third time point.
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16. A blood coagulation analyzing apparatus comprising an analysis controller that perform operations comprising:
calculating a coagulation time based on data representing a change in an optical detection value of a blood specimen added with a reagent for starting a coagulation reaction, the optical detection value representing amount of light transmitted through the blood specimen added with the reagent; and
determining whether an early reaction error has occurred based on a comparison result obtained by comparing an index value related to derivatives calculated concerning a coagulation curve represented by the data, to a predetermined threshold, wherein the index value comprises at least one of:
a time period from a first time point at which the reagent is added to a second time point at which a minimum value of a first derivative calculated concerning the coagulation curve is obtained;
an absolute value of the minimum value of the first derivative calculated concerning the coagulation curve;
an integral value of a difference between: the optical detection values in a time period from a third time point at which a predetermined time elapses from the first time point to a fourth time point at which a minimum value of a second derivative calculated concerning the coagulation curve is obtained; and the optical detection value at the third time point; or
a ratio of:
the difference between the optical detection value at the fourth time point and the optical detection value at the third time point; to
a difference between an optical direction value at a fifth time point at which the coagulation reaction is regarded as stopped and the optical detection value at the third time point.
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