US 11,747,312 B2
Fluidic configuration for a multidimensional liquid chromatography system
Michael O. Fogwill, Uxbridge, MA (US); Sylvain Gilles Cormier, Mendon, MA (US); Thomas Swann, Hopedale, MA (US); and Francis Patrick Tracey, Medway, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on May 4, 2021, as Appl. No. 17/307,389.
Claims priority of provisional application 63/021,396, filed on May 7, 2020.
Prior Publication US 2021/0349060 A1, Nov. 11, 2021
Int. Cl. G01N 30/46 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/468 (2013.01) [G01N 30/463 (2013.01); G01N 2030/027 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A multidimensional liquid chromatography system, comprising:
a switching valve operable in at least two valve states;
a detector in communication with the switching valve through a first fluidic path defined by tubing having a first end coupled to a port of the switching valve and a second end coupled to the detector for coupling the switching valve to the detector;
a routing valve in communication with the switching valve through a second fluidic path defined by tubing having a first end coupled to another port of the switching valve and a second end coupled to a first port of the routing valve for coupling the switching valve to the routing valve; and
a first fluidic loop valve in communication with the routing valve through a third fluidic path defined by tubing having a first end coupled to a second port of the routing valve and a second end coupled to the first fluidic loop valve for coupling the routing valve to the first fluidic loop valve,
wherein a volume of the first fluidic path is substantially equal to a sum of a volume of the second fluidic path and a volume of the third fluidic path.