US 11,747,297 B2
Enhanced chloride selective membrane
Bo Peng, Boulder, CO (US); and David Thompson, Kennett Square, PA (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Filed on Mar. 1, 2022, as Appl. No. 17/652,937.
Application 17/652,937 is a continuation of application No. 15/572,000, granted, now 11,293,892, previously published as PCT/US2016/032814, filed on May 17, 2016.
Claims priority of provisional application 62/162,843, filed on May 18, 2015.
Prior Publication US 2022/0187236 A1, Jun. 16, 2022
Int. Cl. G01N 27/333 (2006.01); G01N 27/30 (2006.01); G01N 27/414 (2006.01)
CPC G01N 27/3335 (2013.01) [G01N 27/301 (2013.01); G01N 27/414 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A chloride selective electrode for detecting chloride in multiple biological samples, the chloride selective electrode comprising:
an inert substrate;
a chloride sensitive membrane formed on the inert substrate, wherein the chloride sensitive membrane is provided with a plurality of quaternary functional groups, and wherein the chloride sensitive membrane comprises:
an epoxide-based matrix dispensed on the inert substrate, wherein the epoxide-based matrix comprises an epoxy resin having a predetermined number of epoxide groups per molecule;
a mixture of an amino compound and an activator dispensed onto a surface of the epoxide-based matrix, wherein the amino compound and activator are present in the mixture in a stoichiometric amount relative to the number of epoxide groups in the epoxide-based matrix, and wherein the stoichiometric amount is in a range of from about 0.5:1 to about 1.5:1, and wherein the mixture comprises reactive species; and
wherein the chloride sensitive membrane is stable for at least 14 days upon exposure to at least one biological sample.