US 11,747,199 B2
At-home blood phenylalanine measuring device for phenylketonuria and applications thereof
Richard D. Shunnarah, Atlanta, GA (US); Hugh F. Garvey, Seminole, FL (US); Lenzi J. Williams, Clearwater, FL (US); and Devon Fish, Fargo, FL (US)
Assigned to METGEN, INCORPORATED, Atlanta, GA (US)
Filed by MetGen, Incorporated, Atlanta, GA (US)
Filed on Aug. 16, 2022, as Appl. No. 17/888,621.
Claims priority of provisional application 63/234,771, filed on Aug. 19, 2021.
Prior Publication US 2023/0057894 A1, Feb. 23, 2023
Int. Cl. G01J 3/02 (2006.01); G01N 33/52 (2006.01); G01N 21/65 (2006.01); G01J 3/44 (2006.01); G01N 33/68 (2006.01)
CPC G01J 3/0272 (2013.01) [G01J 3/0256 (2013.01); G01J 3/4412 (2013.01); G01N 21/658 (2013.01); G01N 33/523 (2013.01); G01N 33/6812 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting phenylalanine (Phe) in a sample collected from a subject, the device comprising:
a laser generator configured to produce a laser beam;
a nanoporous anodic aluminum oxide (NAAO) substrate configured to receive the sample collected from the subject; wherein the laser beam reaches the sample on the NAAO substrate and is reflected or deflected to produce a light signal; and
a light sensor configured to receive the light signal reflected or deflected from the sample;
wherein the device is handheld and detects the Phe in the sample;
wherein the NAAO substrate comprises a multilayered nanoporous aluminum layer.