US 11,746,377 B2
Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support
Senthilkumar Sadhasivam, Mason, OH (US); Vidya Chidambaran, Cincinnati, OH (US); John McAuliffe, Cincinnati, OH (US); Kejian Zhang, Cincinnati, OH (US); Jaroslaw Meller, Cincinnati, OH (US); Cynthia A. Prows, Cincinnati, OH (US); and Tsuyoshi Fukuda, Cincinnati, OH (US)
Assigned to CHILDREN'S HOSPITAL MEDICAL CENTER, Cincinnati, OH (US)
Filed by CHILDREN'S HOSPITAL MEDICAL CENTER, Cincinnati, OH (US)
Filed on Jun. 19, 2020, as Appl. No. 16/946,401.
Application 16/946,401 is a continuation of application No. 16/850,537, filed on Apr. 16, 2020, granted, now 11,597,978.
Application 16/850,537 is a continuation of application No. 15/915,581, filed on Mar. 8, 2018, granted, now 10,662,476.
Application 15/915,581 is a continuation of application No. 14/361,946, granted, now 9,944,985, previously published as PCT/US2012/067111, filed on Nov. 29, 2012.
Claims priority of provisional application 61/661,073, filed on Jun. 18, 2012.
Claims priority of provisional application 61/565,400, filed on Nov. 30, 2011.
Prior Publication US 2020/0340061 A1, Oct. 29, 2020
Int. Cl. C07H 21/04 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6883 (2018.01); C12Q 1/6806 (2018.01)
CPC C12Q 1/6883 (2013.01) [C12Q 1/6806 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/172 (2013.01)] 3 Claims
 
1. A method for treating a human patient for post-operative pain, the method comprising the steps of
a) obtaining a biological sample from a patient in need of treatment for post-operative pain, wherein the biological sample is obtained prior to administering an opioid analgesic to the patient,
b) genotyping the biological sample from the patient to determine the patient's genotype at a single nucleotide polymorphism (SNP) of the ATP binding cassette B1 (ABCB1) gene identified by rs9282564,
wherein the genotyping is performed using one or more of a PCR-based technique for nucleic acid amplification from the sample, gel electrophoresis, mass spectrometry, and microarray hybridization,
c) identifying the presence of a G allele at ABCB1 rs9282564 in the biological sample, and
d) administering an analgesic for post-operative pain to the patient having an allele identified in step c),
wherein the analgesic is selected from the group consisting of acetaminophen, a non-steroidal anti-inflammatory drug (NSAID), dexmedetomidine, clonidine, and combinations and derivations thereof.