CPC C12N 5/0676 (2013.01) [A61K 31/437 (2013.01); A61K 38/22 (2013.01); A61P 3/10 (2018.01); A61P 5/48 (2018.01); C12N 2501/335 (2013.01); C12N 2501/727 (2013.01)] | 13 Claims |
1. A method of increasing cell proliferation in a population of human pancreatic beta cells, said method comprising:
contacting a population of human pancreatic beta cells with a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and a glucagon-like peptide-1 receptor (GLP1R) agonist, wherein said contacting is carried out under conditions effective to cause a synergistic increase in cell proliferation in the population of human pancreatic beta cells.
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