US 11,746,317 B2
Massively parallel, multiple-organ perfusion control system
Ronald S. Reiserer, Nashville, TN (US); Gregory B. Gerken, Nashville, TN (US); David K. Schaffer, Nashville, TN (US); and John P. Wikswo, Brentwood, TN (US)
Assigned to VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed by VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed on Nov. 9, 2022, as Appl. No. 17/984,151.
Application 17/984,151 is a continuation in part of application No. 17/947,302, filed on Sep. 19, 2022.
Application 17/947,302 is a continuation of application No. 17/578,966, filed on Jan. 19, 2022, granted, now 11,447,734, issued on Sep. 20, 2022.
Application 17/947,302 is a continuation of application No. 17/984,151.
Application 17/984,151 is a continuation in part of application No. PCT/US2021/042179, filed on Jul. 19, 2021.
Application PCT/US2021/042179 is a continuation in part of application No. 17/623,350, granted, now 11,565,256, previously published as PCT/US2020/040061, filed on Jun. 29, 2020.
Claims priority of provisional application 63/300,321, filed on Jan. 18, 2022.
Claims priority of provisional application 63/277,329, filed on Nov. 9, 2021.
Claims priority of provisional application 63/257,149, filed on Oct. 19, 2021.
Claims priority of provisional application 63/163,160, filed on Mar. 19, 2021.
Claims priority of provisional application 63/139,138, filed on Jan. 19, 2021.
Claims priority of provisional application 63/053,388, filed on Jul. 17, 2020.
Claims priority of provisional application 62/868,303, filed on Jun. 28, 2019.
Prior Publication US 2023/0121352 A1, Apr. 20, 2023
Int. Cl. C12M 1/00 (2006.01); C12M 1/24 (2006.01); C12M 1/22 (2006.01); C12M 3/06 (2006.01); C12M 3/04 (2006.01); C12M 1/36 (2006.01); C12M 1/42 (2006.01); C12M 1/32 (2006.01); C12M 1/06 (2006.01); F16K 99/00 (2006.01)
CPC C12M 29/10 (2013.01) [C12M 23/08 (2013.01); C12M 23/10 (2013.01); C12M 23/12 (2013.01); C12M 23/16 (2013.01); C12M 23/50 (2013.01); C12M 23/58 (2013.01); C12M 27/02 (2013.01); C12M 27/12 (2013.01); C12M 35/02 (2013.01); C12M 35/04 (2013.01); C12M 41/48 (2013.01); F16K 99/0013 (2013.01); F16K 99/0015 (2013.01); F16K 99/0023 (2013.01); F16K 99/0028 (2013.01)] 52 Claims
OG exemplary drawing
 
1. A fluidic cartridge, comprising:
a fluidic disk having a plurality of alignment openings;
a fluidic chip comprising a body having a first surface and an opposite, second surface, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the first surface, wherein the plurality of protrusions are received in the plurality of alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk;
an actuator operably engaging with the one or more channels at the second surface of the body for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates;
a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein;
a means for mounting a motor for operably driving the actuator to be activated or deactivated; and a means for detachably connecting the motor to the actuator, wherein the mounting means comprises a motor plate or motor support structure on which the motor is mounted; and
an array plate or other support structure attached to the motor plate or motor support structure for locating the fluidic cartridge relative to the motor.