US 11,746,161 B2
Antibodies that specifically bind PD-1 and methods of use
Qiang Chen, San Diego, CA (US); Suzanne Cole, Spring House, PA (US); Karen Duffy, Spring House, PA (US); Yanxia Guo, Spring House, PA (US); Debra Gardner, Spring House, PA (US); Damon Hamel, San Diego, CA (US); Shannon Hitchcock, Spring House, PA (US); Ann Lacombe, San Diego, CA (US); Jinquan Luo, Spring House, PA (US); Ravi Malaviya, Spring House, PA (US); Yevgeniya Orlovsky, Spring House, PA (US); Pejman Soroosh, San Diego, CA (US); Melissa Swiecki, Spring House, PA (US); and Deepti Wilkinson, San Diego, CA (US)
Assigned to Janssen Biotech, Inc., Horsham, PA (US)
Filed by Janssen Biotech, Inc., Horsham, PA (US)
Filed on Dec. 17, 2020, as Appl. No. 17/125,263.
Application 17/125,263 is a division of application No. 15/997,148, filed on Jun. 4, 2018, granted, now 10,995,149.
Claims priority of provisional application 62/673,185, filed on May 18, 2018.
Claims priority of provisional application 62/648,114, filed on Mar. 26, 2018.
Claims priority of provisional application 62/515,188, filed on Jun. 5, 2017.
Prior Publication US 2021/0102000 A1, Apr. 8, 2021
Int. Cl. C07K 16/40 (2006.01); A61P 37/06 (2006.01); C07K 16/06 (2006.01); A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01); C12N 15/00 (2006.01)
CPC C07K 16/40 (2013.01) [A61K 39/3955 (2013.01); A61P 37/06 (2018.01); C07K 16/065 (2013.01); C07K 16/18 (2013.01); C07K 16/2818 (2013.01); C12N 15/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/57 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 15 Claims
 
1. An isolated polynucleotide comprising one or more nucleotide sequence(s):
a) encoding the heavy chain variable region (VH) of SEQ ID NO: 118;
b) encoding the light chain variable region (VL) of SEQ ID NO: 119;
c) encoding the VH of SEQ ID NO: 118 and the VL of SEQ ID NO: 119;
d) encoding the VH of SEQ ID NO: 10;
e) encoding the VL of SEQ ID NO: 16;
f) encoding the VH of SEQ ID NO: 10 and the VL of SEQ ID NO: 16; or
g) comprising the polynucleotide sequence of SEQ ID NO: 13, 19, 132 or 133.