US 11,746,135 B2
Thermostable FGF2 polypeptide, use thereof
Petr Dvorak, Ricmanice (CZ); Pavel Krejci, Brno-Venkov (CZ); Lukas Balek, Klimkovice (CZ); Livia Eiselleova, Mocenok (SK); Zaneta Konecna, Pardubice (CZ); Pavel Dvorak, Brno (CZ); David Bednar, Brno (CZ); Jan Brezovsky, Brno (CZ); Eva Sebestova, Tisnov (CZ); Radka Chaloupkova, Zamberk (CZ); Veronika Stepankova, Slavkov u Brna (CZ); Pavel Vanacek, Slavkov u Brna (CZ); Zbynek Prokop, Brno (CZ); Jiri Damborsky, Brno (CZ); and Michaela Bosakova, Brno (CZ)
Assigned to Masarykova Univerzita, Brno (CZ); and Enantis s.r.o., Brno (CZ)
Appl. No. 15/778,743
Filed by Masarykova Univerzita, Brno (CZ); and Enantis s.r.o., Brno (CZ)
PCT Filed Oct. 3, 2016, PCT No. PCT/EP2016/073567
§ 371(c)(1), (2) Date May 24, 2018,
PCT Pub. No. WO2017/089016, PCT Pub. Date Jun. 1, 2017.
Claims priority of application No. 15196802 (EP), filed on Nov. 27, 2015.
Prior Publication US 2020/0270320 A1, Aug. 27, 2020
Int. Cl. C07K 14/50 (2006.01); C12N 5/00 (2006.01)
CPC C07K 14/503 (2013.01) [C12N 5/0018 (2013.01); C12N 2501/115 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A thermostable polypeptide possessing FGF2 activity and having at least 92% sequence identity to SEQ ID NO: 2, and comprising at least an amino acid substitution R31L.